The England striker missed the midweek draw with Benfica due to a hip injury picked up against Swansea, but is back in the first XI for the visit of the in-form Magpies
The England forward missed the Champions League draw with Benfica in midweek but has been deemed fit enough to face the in-form Magpies at Old Trafford.
Meanwhile, fellow striker Danny Welbeck is still not ready to feature, as United try to move to within two points of rivals Manchester City at the top of the table with a win against Alan Pardew's men.
But the Magpies are also in good form, sitting fourth in the table, and have star striker Demba Ba in their line-up, as well as playmaker Hatem Ben Arfa, who is returning to form after a year out with a broken leg.
Manchester United starting XI: De Gea; Fabio, Vidic, Ferdinand, Evra; Nani, Giggs, Carrick, Young; Hernandez, Rooney
Subs: Lindegaard, Macheda, Gibson, Valencia, Evans, Smalling, Park.
Newcastle starting XI: Krul; Simpson, S.Taylor, Coloccini, R.Taylor; Obertan, Guthrie, Cabaye, Gutierrez; Ben Arfa; Ba.
Subs: Elliot, Perch, Santon, Gosling, Sammy Ameobi, Shola Ameobi, Lovenkrands