Visitors make changes and go with an attacking line-up in bid to stay comfortably clear of rivals United at top of the Premier League table
Aleksandar Kolarov comes into the starting line-up, after starting on the bench in the away win against Villarreal in mid-week. Meanwhile, Samir Nasri loses his starting place and moves to the bench, along with Mario Balotelli.
Vincent Kompany is out of the squad altogether due to a suspension, so Stefan Savic starts. Nigel de Jong also does not make the squad.
City will be looking for another good performance, following the convincing 3-0 win in the Champions League, to spoil Sir Alex Ferguson's celebrations for his 25th anniversary.
As for QPR, Danny Gabbidon starts in place of Fitz Hall, injured in the 3-1 defeat to Tottenham last Sunday. Jay Bothroyd also gets a start for the home side, in place of Adel Taarabt who is not in the match squad.
Other changes for the home side are a start for Jamie Mackie, while Jason Puncheon, Bruno Andrade, Shaun Derry and Bradley Orr make the bench.
The London club will be looking for a better result today, after losing 3-1 to capital rivals Spurs in their last game.
QPR starting XI: Kenny; Young, Gabbidon, Ferdinand, Traore; Wright-Phillips, Barton, Faurlin, Mackie; Bothroyd, Helguson.
Subs: Murphy, Orr, Hill, Derry, Smith, Andrade, Puncheon.
Manchester City starting XI: Hart; Richards, Lescott, Savic, Kolarov; Yaya Toure, Barry; Milner, Aguero, Silva; Dzeko.
Subs: Pantilimon, Zabaleta, Clichy, Kolo, A. Johnson, Nasri, Balotelli.