Five of the 'big six' are in action, including both Manchester clubs, while Newcastle United aim to maintain their unbeaten start to the season at home to Everton
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from how Manchester City get on as they look to avoid a shock against QPR, to whether Sir Alex Ferguson can celebrate 25 years in charge at Old Trafford with a win.
Click on the link below and you can follow all the matches this afternoon, beginning with the 12:45 kick-off between Newcastle United and Everton:
Five matches then get under way at 15:00, including West Brom's trip to Arsenal, Chelsea's clash with Blackburn Rovers and Manchester United's game against Sunderland.
Elsewhere, Aston Villa host Norwich City and Swansea travel to Liverpool, while Manchester City face QPR at Loftus Road in the evening kick-off.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.
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