The Reds skipper is back in the side as Andy Carroll misses out while Phil Jones starts in midfielder for the Red Devils and Javier Hernandez must settle for a place on the bench
Gerrard came on as a substitute in the Merseyside derby before the international break and is now fit to start, meaning that Andy Carroll has been dropped to the bench despite scoring his first Premier League goal of the season against Everton.
Gerrard will be making his first start for Liverpool in seven months as they look to build on their three consecutive victories over Manchester United at Anfield.
United have made six changes from their last win against Norwich before the international break, with Rooney and Javier Hernandez dropping to the bench.
Rooney will have to be content with a place among the substitutes after recent well-publicised issues on and off the pitch, meaning Danny Welbeck starts up-front on his own.
Phil Jones has been selected ahead of Michael Carrick in the holding midfield position at Anfield as Sir Alex looks to keep the returning Gerrard quiet.
Liverpool starting XI: Reina; Kelly, Carragher, Skrtel, Enrique; Lucas, Adam, Gerrard; Downing, Kuyt, Suarez.
Subs: Doni, Bellamy, Carroll, Henderson, Spearing, Robinson, Agger.
Manchester United starting XI: De Gea; Smalling, Ferdinand, Evans, Evra; Park, Jones, Fletcher, Young; Giggs; Welbeck.
Subs: Lindegaard, Rooney, Nani, Anderson, Hernandez, Carrick, Valencia.