Kenny Dalglish and Sir Alex Ferguson go head-to-head for the first time this season, while Andre Villas-Boas' side aim to keep up the pressure at the top against the Toffees
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from the team news ahead of the early kick-off between Liverpool and Manchester United, to how Didier Drogba fares in the absence of Fernando Torres as Chelsea take on Everton.
Click on the link below and you can follow all the matches this afternoon, beginning with the 12:45 kick-off at Anfield:
Five matches get under way at 15:00, with Manchester City hosting Aston Villa, Norwich City facing Swansea City at Carrow Road and Blackburn Rovers travelling to QPR.
Elsewhere, Stoke City play Fulham at the Britannia Stadium and Wigan Athletic host Bolton Wanderers, while Everton travel to Chelsea in the late kick-off.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.