A win would leave Liverpool just three points behind the current league leaders and Dalglish added that he hoped to take the opportunity to set United back in the title race.
"People say this is the biggest game of the season but I don't look at any game as being big or small," Dalglish told reporters. "It's another game, another three points for a win.
"The only difference this time is the fact that, if we win, we will move a bit closer to them.
"It's an opportunity to help yourself and dent their chances at the same time."Liverpool have won their last three matches against United at Anfield but Dalglish maintained that his players would not be resting on their laurels this time around.
"We know what we're up against and so do they," he said. "Nobody will have an easy 90 minutes. That's what the Premier League is all about.
"In this fixture last season, we got our reward for playing very well and won 3-1.
"But we won't get anything on Saturday because of what we did the last time we faced off against them."
Dalglish explained that the late return of players from international duty this week will have made preparation tricky for both clubs, but admitted that Sir Alex Ferguson has dealt with the injuries handed to him very well so far this season.
"United have started the season very well," he said. "They're sitting on top at the moment and that's where everybody wants to be.
"They've had a lot of injuries too but coped well with them. Like all managers, Fergie is waiting to see how his players are after playing for their countries.
"We will have to see how fit or otherwise everyone is when they come back from international duty before we can properly prepare for the weekend."
The former Scotland international also elaborated on the reasoning behind the arrangement of a friendly against Scottish Premier League champions Rangers, which will be played on Tuesday next week.
"Gaining experience is vital no matter what level you are — that's why we've organised this," he said.
"It may be a friendly but it's very important for us. A lot of the players we have bought don't have any European experience at club level.
"It may sound strange to refer to this as gaining European experience when we're only going to Scotland, but we'll face a different team away from home.
"It won't do us any harm to play in that different environment."