Redknapp has revealed that the Togolese international picked up a hamstring strain in the 2-1 victory over Arsenal in Spurs' last Premier League outing.
Whilst the 64-year-old is hopeful Adebayor may be fit in time for the fixture at St James’ Park, he is also cautious that a return to action to soon for the on-loan Manchester City striker could only worsen the injury.
Speaking to Sky Sports News, Redknapp said: "He has got a bit of a hamstring [problem].He played on with it last week. He did it in the first half against Arsenal and he played on, which is not easy. He did have a tear. It's touch and go for him really.
"It's a dangerous one. If he tears it badly, he has got a grade one tear if he makes a real mess of it and he could be out for six or seven weeks.
"It's a difficult one to risk him, but we will see how he feels. We will give him a couple of days yet, keep treating him and hopefully he could be okay.
"If he is a doubt, I wouldn't want to risk him. I wouldn't want to lose him long term.''
Redknapp also expressed similar concerns over Van der Vaart, who also may be sidelined with a recurring hamstring problem that was once again exasperated on international duty last week.
"He sometimes has a problem with that,'' he added. "He has had a few hamstring [injuries] since he's been with us, but he's important to us - he scores goals. He's an amazing finisher."
Tottenham’s injury woes may be compounded before the weekend’s clash with Verdan Corluka, Sandro and Niko Kranjcar all facing late fitness tests.