The early kick-off comes from Goodison Park for the Merseyside derby, while the Manchester clubs are in action later in the day as they continue to battle for top spot
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from the number of bookings and red cards in the Merseyside derby, to whether Manchester United, Manchester City, Newcastle United and Aston Villa can maintain their unbeaten starts.
Click on the link below and you can follow all the matches this afternoon, beginning with the 12:45 kick-off between Everton and Liverpool:
Five matches get under way at 15:00, with Villa hosting Wigan Athletic, Roberto Mancini's City travelling to Blackburn Rovers and Manchester United facing Norwich City.
Elsewhere, Newcastle travel to Wolves, while Sunderland play West Brom at the Stadium of Light.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.