The French centre-back says the Uruguayan will be "another great test" for him on Saturday, and admits that he is not pushing the club to give him a two-year deal
Distin faced the Argentine last weekend when the Toffees travelled to the Etihad Stadium and went down to a 2-0 defeat, and faces Suarez for the first time in the Merseyside derby on Saturday.
The 34-year-old had high praise for the Uruguayan, but is confident he can cope with the challenge he poses.
He told The Liverpool Echo: “Luis seems to be a great player, an amazing player with great quality who can score goals. But he won’t be the first great striker I have played against.
“I have been here for 10 years, I don’t know how many games I have played, but I have played against players like Thierry Henry, Alan Shearer, Didier Drogba, Nicolas Anelka, Fernando Torres. I could give you 50 names of top strikers I have played against.
“I played against [Edin] Dzeko and Aguero last weekend, so it is just going to be another good challenge, and one which I will enjoy. I can’t wait.
“I actually think Aguero and Suarez are very similar in the way they are built physically, and the way they play. It will be another good test.”
Distin has also rejected reports that he is holding out for a two-year contract with Everton.
The Frenchman's deal expires at the end of the season but he insists he would be happy to stay on different terms if the club offered them.
“I read today in the newspaper that I was asking for a two-year contract," he said.
"I am not sure where that has come from but it is completely untrue, and I would like to rectify that.
“I am happy with one year. If Everton want to give me two then that is all good, but I am really happy with one.”
Distin spent much of the game against Manchester City hard at work as Everton employed a defensive strategy in an attempt to contain City's attacking threat, but believes they will look to attack their Merseyside rivals.
“There was a lot of defending to do but that was just a one-off game,” he added.
“It is not the Everton style. We play our football and try to win the game. That is a strength of ours.
“It is a home game as well, so we will not be going out just to defend. We want to win.”