Roberto Mancini's men look to end their recent poor record against the Toffees in the early kick off, while the Red Devils aim to maintain their 100 per cent league record
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from how Manchester City line up at home to Everton, to whether Manchester United can maintain their 100 per cent start in the league.
Click on the link below and you can follow all the matches this afternoon, beginning with the 12:45 kick-off between City and Everton:
Six matches get under way at 15:00, with Arsenal hosting Bolton Wanderers, Chelsea facing Swansea City at Stamford Bridge and Wolves travelling to Liverpool.
Elsewhere, Newcastle United play Blackburn Rovers, West Brom host Fulham and Tottenham travel to Wigan Athletic, while Stoke City face Manchester United in the evening kick-off.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.