The north Londoners, with just a solitary point from their opening three games, include both men in their starting line-up whilst three more new recruits Yossi Benayoun, Andre Santos and Chu Young Park start on the bench.
Elsewhere Theo Walcott and Kieran Gibbs are both fit and take their places and midfielder Emmanuel Frimpong also returns from suspension.
Swansea City, meanwhile, travel to the capital hoping to register their first Premier League goal of the season after having drawn blanks in their opening three games against Sunderland, Wigan Athletic and Manchester City.
Teams in full:
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Frimpong; Arteta, Ramsey, Walcott; Arshavin, Van Persie (c). Subs: Fabianski, Santos, Djourou, Benayoun, Chamakh, Park.