Arsene Wenger's side look to bounce back from their 8-2 humiliation at Old Trafford a fortnight ago, while the Red Devils aim to continue their unbeaten start to the season
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from how Arsenal fare following their 8-2 hammering at the hands of Manchester United, to whether Sir Alex Ferguson's men can keep up their unbeaten start.
Click on the link below and you can follow all the matches this afternoon:
Six matches get under way at 15:00, with Arsenal hosting Swansea City, Liverpool travelling to Stoke City and Manchester City facing Wigan Athletic.
Elsewhere, Everton host Aston Villa, Chelsea travel to Sunderland and Tottenham play Wolves at Molineux.
And the day's late kick-off sees Manchester United play Bolton Wanderers at the Reebok Stadium, which you can follow by getting kick-by-kick text updates here.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.