Arsene Wenger’s depleted side host the Reds in one of two early kick-offs, while Andre Villas-Boas aims to pick up his first win as Blues boss away to the Baggies
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from how Arsene Wenger's under-strength Arsenal side line up against Liverpool to whether West Brom can cause an upset against Chelsea.
Click on the link below and you can follow all the matches this afternoon, beginning with the Tyne-Wear derby between Sunderland and Newcastle:
Arsenal and Liverpool will be looking to pick up their first three points of the season in another of today’s early kick-offs, while Chelsea host West Brom at 17:30. You can follow both games on our Premier League LIVE! or by getting kick-by-kick text updates.
Elsewhere, Alex McLeish takes charge of his first home match as Aston Villa boss against Blackburn, Everton face QPR and Roberto Martinez returns to Swansea for the first time since leaving to join Wigan.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.