The Costa Rican forward, who has also been linked with a move to Tottenham, claims a move to Craven Cottage may be a realistic option after the club made contact with his agent
The Costa Rican has been linked with a move away from the Eredivisie this summer, with Tottenham boss Harry Redknapp even attending Twente's Champions League play-off tie against Benfica to watch the player.
But Ruiz has now confirmed that Spurs' London rivals have made contact with his agent over a possible move.
While Ruiz says he would be happy to stay in the Netherlands, he admits the lure of Premier League football could be too good to turn down.
"Fulham are a serious option for me," he told Dutch newspaper Telegraaf.
"They also play in the Premier League and that's a great competition. Fulham have contacted my agent. We are open to talks if they make a concrete offer."
Ruiz also told his current employers that even though there is speculation regarding his future, it would not be a problem if he failed to land a move to England.
"I am not thinking about a transfer too much, because I can't do anything about what happens," he added.
"Obviously, I'm keen to make a step forward. It's not a problem for me though if I eventually stay at Twente."