The Reds, with new signings Jordan Henderson, Charlie Adam and Stewart Downing, host the Black Cats in one of the stand-out matches, while Wenger’s side travel to St James’ Park
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With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from how Liverpool’s new signings fare on their debuts to whether Arsenal can cope without Cesc Fabregas and Samir Nasri.
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The stand-out fixture taking place at 15:00 is between Liverpool and Sunderland, where Jordan Henderson faces his former club on his Reds debut.
Elsewhere, Blackburn host Wolves and Aston Villa travel to Fulham, while Premier League new boys QPR and Norwich begin life back in the top flight against Bolton and Wigan respectively.
We will also bring you updates during the evening kick-off between Newcastle and Arsenal, which you can follow both on our Premier League LIVE! or by getting kick-by-kick text updates here.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.