The Argentina forward is suffering from blisters and has missed a number of training sessions for his new club leading up to the tie against Sir Alex Ferguson's side at Wembley
Sergio Aguero is a doubt for Manchester City's Community Shield tie against Manchester United on Sunday, according to reports.
The 23-year-old, who completed his £35 million switch to Eastlands last month, is suffering from blisters and has been unable to train with the squad in the build-up to their Wembley clash.
The Sun report that the Argentina international is still in contention of featuring for Roberto Mancini's side but may have to settle for a place on the bench.
With Carlos Tevez still on leave following his Copa America exploits in July, Mario Balotelli and Edin Dzeko are the likely pairing to face the Premier League champions.