Two of five teams will join West Ham in being relegated to the Championship, while Manchester City and Arsenal look to avoid a Champions League play-off by finishing third
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League action to life on your computer - from how the relegation battle shapes up throughout the afternoon to whether Arsenal can pip Manchester City to third place.
Click on the link below and you can follow all the matches this afternoon:
All 10 of today’s matches kick off at 16:00, eight of which you can follow both on our Premier League LIVE!, or by getting kick-by-kick text updates with our live commentary service.
The stand-out game of the day comes from Old Trafford, where champions Manchester United host 18th-placed Blackpool, while fellow strugglers Wigan and Birmingham travel to Stoke and Tottenham respectively.
Elsewhere, two sides who are still fighting against the drop, Wolves and Blackburn, face each other at Molineux, while Manchester City play Bolton at the Reebok Stadium and Arsenal face Fulham away as the race for third place continues.
The battle for the final Europa League place is still ongoing, with Aston Villa hosting a Liverpool side who can finish fifth if other results go their way.
Chelsea are also in action as they face Everton, while relegated West Ham host Sunderland and Newcastle play West Brom.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.