Defender and midfielder are reportedly set to miss not only the weekend game against the Seasiders, but the all-important fixture against Roberto Mancini's men next weekhere.
Tottenham are reportedly to be without Benoit Assou-Ekotto and Tom Huddlestone for the upcoming games against Blackpool and Manchester City.
Spurs are currently chasing a European spot after dropping to sixth in the table, but are level on points and have a game in hand over fifth-placed Liverpool.
Assou-Ekotto is nursing a hamstring injury while Huddlestone is currently out with an ankle problem, and now The Telegraph claims that the duo are set to be sidelined against the Seasiders and Roberto Mancini's men.
Tottenham will move into fifth place if they avoid defeat against Blackpool on Saturday.