The £35m man isn't deemed fit enough to face his old side while youngsters Flanagan and Spearing continue their run in the side as Reds aim to reclaim fifth spot
The 22-year-old made a £35 million move to Merseyside in the winter transfer window, and scored his first two Liverpool goals in the recent 3-0 victory over Manchester City.
But it appears that the youngster has not been able to regain his fitness in time for this game, and he starts from the bench.
Glen Johnson, however, has managed to recover from a hamstring injury sustained against West Bromwich Albion earlier in the season, and now returns to the starting line-up.
Newcastle have named an unchanged line-up from the one that recently carved out a draw against Blackpool.
Liverpool: Reina; Johnson, Carragher, Skrtel, Flanagan; Maxi, Lucas, Spearing Meireles; Kuyt, Suarez. Subs: Gulacsi, Kyrgiakos, Robinson, Shelvey, Cole, Ngog, Carroll.
Newcastle: Krul; Simpson, Coloccini, Williamson, Enrique; Barton, Nolan, Tiote, Gutierrez, Ameobi, Lovenkrands. Subs: Harper, Tavernier, R. Taylor, S. Taylor, Ranger, Ferguson, Kuqi.