Dimitar Berbatov misses out through injury for the league leaders while John Heitinga has failed a fitness test for the Toffees
The league leaders will be without Dimitar Berbatov, who has failed to recover from a groin strain, while they are also without Paul Scholes through suspension, and Darren Fletcher who is yet to fully recover from a virus.
Everton welcome back Tim Cahill, though the talismanic Australian is only fit enough for a place on the bench.
John Heitinga has failed a late fitness test on a hamstring problem which forced him off against Blackburn while the game against Manchester United has come to soon for Mikel Arteta to make a long awaited return.
Manchester United will be hoping for a win ahead of Premier League games against Chelsea and Arsenal which are likely to decide where the trophy will end up this season.
Manchester United: Van der Sar; O'Shea, Ferdinand, Evans, Fabio; Valencia, Gibson, Anderson, Nani; Rooney, Hernandez.
Subs: Kuszczak, Evra, Brown, Owen, Giggs, Carrick, Rafael.
Everton: Howard; Hibbert, Jagielka, Distin, Baines; Coleman, Neville, Rodwell, Osman, Bilyaletdinov; Beckford.
Subs: Mucha, Cahill, Gueye, Vellios, Anichebe, Mustafi, Duffy.
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