Red Devils will hope to extend their lead at the top of the table as they face the Toffees in the early kick-off, while Carlo Ancelotti's men look to keep their title hopes alive
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from how Manchester United fare as they look to continue their march towards the title to whether Fernando Torres starts for Chelsea.
Click on the link below and you can follow all the matches this afternoon, beginning with the 12:45 kick-off between Manchester United and Everton:
Later in the day we have six games kicking off at 15:00, including Liverpool playing host to Birmingham and West Brom travelling to Tottenham, which you can follow both on our Premier League LIVE!, or by getting kick-by-kick text updates with our live commentaries of each game.
Elsewhere, Aston Villa face Stoke, Newcastle travel to Blackpool, struggling Sunderland play Wigan and Wolves look to climb out of the relegation zone at home to Fulham. And we will also bring you updates from Stamford Bridge for the evening kick-off between Chelsea and West Ham.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.