Theo Walcott and Johan Djourou also make returns to the Arsenal side for a game that Arsene Wenger has conceded his team must win to stay in the title race.
Liverpool, fresh from the success of their 3-0 thumping of Manchester City pair Andy Carroll and Luis Suarez up front together and will be hoping the pair link up as effectively as they did in their impressive performances against Roberto Mancini's men.
Arsenal: Szczesny; Eboue, Koscielny, Djourou, Clichy; Diaby, Wilshere; Walcott, Fabregas, Nasri; Van Persie.
Subs: Lehmann, Squillaci, Gibbs, Song, Arshavin, Chamakh, Bendtner
Liverpool: Reina; Flanagan, Carragher, Skrtel, Aurelio; Kuyt, Lucas, Spearing, Meireles; Suarez, Carroll.
Subs: Gulacsi, Cole, Kyrgiakos, Shelvey, Ngog, Maxi, Robinson.