The Scot has suggested his players are better prepared for the semi-final as they have played at Wembley more times than their opponents.
“It’s possible,” said Ferguson in an article in The Mirror.
“I don’t know the mental side of any of their players, because I’ve not worked with any of them.
“Only Roberto [Mancini] will know that, he’ll know his players much better. But it’s very difficult to block out [the occasion], simply because sometimes it overrides everything else.
“And Wembley is an occasion stadium. When you go there it’s for an important reason, and that can affect some players. I don’t think there’s any doubt about that. It’s a fact."
Ferguson believes his players' big-game experience could stop their city rivals from winning their first trophy in 35 years.
“I know my own players and they’ve obviously been used to big game situations many times, so we don’t have to conquer that.
“I have a group of players who are confident going into games, their attitude is great and I couldn’t ask for a better situation than I’ve got.
“The players are in form and the squad is getting stronger with players back [from injury].
“It wouldn’t matter which game we were going into, I’d believe in these players.
“At the moment they’ve got a great momentum about them, which is a fantastic thing to have at this stage of the season.”