The Red Devils have also opted to play Wayne Rooney up front on his own with Dimitar Berbatov and Javier Hernandez both on the bench.
West Ham are unchanged from the draw with Tottenham before the international break with Scott Parker passed fit to start after he was a doubt with shoulder and calf injuries.
The league leaders will be aiming to avoid a re-occurrence of their last visit to Upton Park when they were comprehensively beaten 4-0 in the quarter-final of the League Cup.
Teams in full:
West Ham: Green; Jacobsen, Bridge, Da Costa, Upson; Parker, Hitzlsperger, Noble, O'Neil; Ba, Cole. Subs: Boffin; Reid, Tomkins, Spector; Piquionne, Obinna, Keane.
Manchester United: Kuszczak; Fabio, Vidic, Smalling, Evra; Valencia, Gibson, Giggs, Carrick, Park; Rooney. Subs: Amos; Gill, Anderson, Nani; Owen, Berbatov, Hernandez