Sir Alex Ferguson’s men kick the afternoon’s action off at Upton Park, while later on the Gunners will look to keep up their title challenge at home to Rovers
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from how matters at the top and bottom of the table progress throughout the day to whether Roy Hodgson can dent the European challenge of his former club Liverpool.
Click on the link below and you can follow all the matches this afternoon, beginning with the 12:45 kick-off between West Ham and Manchester United:
Later in the day we have six games kicking off at 15:00, including Chelsea's trip to Stoke, West Brom playing host to Liverpool and Tottenham facing Wigan at the DW Stadium, which you can follow both on our Premier League LIVE!, or get kick-by-kick text updates with our live commentaries of each game.
Elsewhere, Birmingham play Bolton, Aston Villa look to ease their relegation worries away to Everton, Newcastle host Wolves and Arsenal hope to keep up with United at the top of the table in the evening kick-off against Blackburn.
With reaction coming in from around the country, Goal.com UK will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.