Javier Hernandez starts in attack for Sir Alex Ferguson's side
The Ivorian has fallen down the Blues packing order since the Spaniard arrived for £50 million in January, but today refused to confirm reports he will leave as a result.
David Luiz - impressive on his Chelsea debut at Fulham - partners John Terry in the centre of defence while Carlo Ancelotti has stuck to his words and switched to a 4-4-2 formation.
For United, Chicharito, who netted twice against Wigan at the weekend, is preferred to Dimitar Berbatov again in attack, parntering Wayne Rooney up front.
Ryan Giggs starts on the bench but will match Bobby Charlton's record of 606 league games for United if he is introduced to the fold.
Berbatov is this season's leading league scorer with 19 goals while Drogba ended the last campaign top of the charts with 29 goals.
Sir Alex Ferguson has named an unchanged side for the first time since May 2008 and insists he was influenced by his team's strong performance over Wigan in their last outing.
"I think there was a good chemistry in the team on Saturday, the front two in particular. It was a good combination, a real threat, and it made the decision easy for me," Ferguson told Sky Sports.
Chelsea: Cech; Ivanovic, Terry, Luiz, Cole; Ramires, Essien, Lampard, Malouda; Torres, Anelka. Subs: Turnbull, Drogba, Mikel, Bosingwa, Zhirkov, Kalou, McEachran
Manchester United: Van der Sar; O'shea, Vidic, Smalling Evra; Nani, Fletcher, Scholes, Carrick, Rooney; Hernandez. Subs: Brown, Berbatov, Giggs, Rafael, Fabio, Gibson, Kuszczak.