With Carson at fault for the opening goal, Di Matteo said: "He is a strong character and I am sure he will want to make it up to the team and everybody.
"If you look at the weekend, there were quite a few mistakes by goalkeepers.
"When a goalkeeper makes a mistake then most of the time it's a goal, but he made a lot of saves for us last season and won us a lot of points and I'm sure he will pay us back.
"As a captain you have certain responsibilities within the dressing room as well as yourself and I am sure he will rise to the occasion. He will be okay."
The Baggies are unbeaten at home since January and the boss wants his team to respond to their opening day defeat, but won’t be putting pressure on his men to keep their unbeaten home record intact.
"There is nothing easy but we have to try our best and I want the team to show a reaction to Saturday," continued Di Matteo.
"I want them to play well, try hard and give us a chance to be able to win a game.
"The home record is good, but it is a different league. We have to do well, and we want to do well, by starting off our season at home well.
"The supporters can make it easier against Sunderland. Our fans have been magnificent, all last year, since I have been here they've been fantastic.
"I think we have repaid them as well with some great games, and results last season."