The Premier League champions' coach believes his side could be in for a difficult job if they were to go after the striker, while also discussing the transfer of Mario Balotelli
The Uruguay international has been heavily linked with a move away from the San Paolo, but the Partenopei have steadfastly insisted that they will only let go of the player if a club matches his €63 million [£54.4m] buy-out clause.
However, even though Gregucci feels Napoli have slapped a high price-tag on the 25-year-old, he believes the prolific striker would be well worth the money.
"I am sure that it will not be easy for us at City to take Cavani. He is well worth his high price-tag and I'm sure that he would score goals at the top 10 clubs in the world," Gregucci told Radio Kiss Kiss.
"His buy-out clause is pretty high and Napoli did a good job to include that in his deal. I feel that it would be money well spent, though. He is worth every cent."
Gregucci went on to discuss the transfer of Mario Balotelli from City to AC Milan, and claimed benefited all three parties.
"I think that everybody won in this transfer," he continued.
"Manchester City receive more money than they paid for him, Milan gain something because Mario can be devastating, and Balotelli can get best to his best without the pressure from the media and focus on his football again."
Balotelli netted twice on his Milan debut as he helped them to a 2-1 win over Udinese at the weekend.