The Blues welcome the 2011-12 champions to Stamford Bridge on Sunday just two points adrift of league leaders Arsenal.
City are a point further back in fourth but the Portuguese - who guided Chelsea to consecutive Premier League crowns in 2005 and 2006 - believes that Manuel Pellegrini's side are most likely to lift the trophy this term.
|10/1||Chelsea are 10/1 with BetVictor to beat Manchester City 1-0|
"Pellegrini can win the title and he has the most important thing, which is an unbelievable squad of players.
"They are a very good team. They have two very good teams - one playing, and another one on the bench and in the stands. A fantastic squad and fantastic players, a really good team."
City will be without captain Vincent Kompany for the game because of a calf problem but Mourinho does not feel that the Belgium international's absence will be a factor.
"It's a surprise for me because I thought he was going to play but it doesn't change [anything]," he added.