The former Netherlands attacker was unable to bring the curtain down with a win after his Catalunya side were denied by a second-half equaliser from the West Africans
Sergio Gonzalez netted a seventh-minute penalty but an excellent breakaway goal from US-based Bright Dike denied the 65-year-old from overseeing a victory in his farewell game.
Cristian Tello squandered a last-minute chance for a Catalan side, who featured the likes of Xavi, Sergio Busquets and Bojan.
Cruyff is a legend in the north east region of Spain, particularly synonymous with Espanyol's local rivals Barcelona, the side he famously led to their first European Cup in 1992.
In an eight-year spell in the Camp Nou dugout, the former playmaker also led Barcelona to four consecutive liga titles between 1991 and 1994.
Cruyff also collected silverware in a three-year stint as coach of Ajax between 1985 and 1988.
The star of Netherlands' run to the 1974 World Cup final also enjoyed a decorated playing career with both Barcelona and Ajax, winning the Ballon d'Or three times.