West Ham United
Scott Parker could return after missing the 3-0 defeat against Liverpool with a virus but Avram Grant could be without Mark Noble after the midfielder suffered a leg injury at Anfield.
West Ham will also be without long term casualties Manuel da Costa (ankle), Jack Collison (knee), Thomas Hitzlsperger (thigh), Anthony Edgar and Peter Kurucz (both knee).
But Grant will be boosted by the return of Valon Behrami and Kieron Dyer in midfield.
Possible starting XI: Green; Spector, Gabbidon, Upson, Illunga; Behrami, Kovac, Parker; Dyer, Cole, Piquionne.
Roberto Martinez is hopeful club captain Gary Caldwell could be fit to make a surprise return to the starting line-up at Upton Park, three weeks ahead of schedule.
But Wigan will still be without injured duo Emmerson Boyce (hamstring) and James McCarthy (ankle).
The Latics will also be without suspended duo Hugo Rodallega and Antolin Alcaraz.
Possible starting XI: Al Habsi; Gohouri, G Caldwell, S Caldwell, Figueroa; Stam, Diame, Thomas, Gomez, N'Zogbia; Di Santo.
Save our season
Desperate times call for desperate measures and at Upton Park these really are desperate times.
With only one win all season and only nine points to their name, West Ham prop up the Premier League table.
For a club surrounded in the history of West Ham it is not good enough and this fact is know by fans, players, management and directors alike.
So much so that Saturday's match against relegation rivals Wigan has been branded the 'save our season' match.
But it is not as easy as cutting ticket prices to generate an intimidating atmosphere at the Boleyn Ground, Avram Grant has to get a performance from his players and they in turn have to play the match of their lives against Roberto Martinez's men.
History is on the Hammers' side as last season they were thrashed by Liverpool but in their next game beat Wigan to help gurantee their survival in the league.
But this season the pressure is telling on Avram Grant and his team, so much so that his assistant manager Zeljko Petrovic was sacked following the side's poor run of form.
There has also been player unrest this week, so if Grant is going to last in his job beyond the weekend he needs a win.
A win will not even take the Hammers out of the drop zone but anything other than that will create clear daylight between the bottom club and Wigan in 18th.
Avoiding the drop
Meanwhile, Wigan will be hoping to climb out of the relegation places with a win.
The Latics will be hopeful of a win against the struggling Hammers but Martinez's side have had their own problems on the road.
They have won only once on their travels and without the suspended Hugo Rodallega they could find it difficult to breach Robert Green.
But whatever happens on Saturday, we do know there will be an intimidating atmosphere awaiting Wigan and how they deal with it could decide the outcome of the game.