The Hammers have lost three games in a row and are just six points ahead of the bottom three, but face a Tigers outfit who have won just three times since the turn of the year
Sam Allardyce's side are now looking over their shoulder after a poor March that has seen them lose all of their Premier League fixtures.
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|16/1||West Ham are 16/1 with bet365 to draw 2-2 with Hull|
West Ham now sit 14th in the table - just six points above the relegation zone - and were overtaken by Hull at the weekend following their 2-0 win over West Brom.
"It is going to be tough. We've still got eight games left and we've got to put some points on the board," West Ham midfielder Mark Noble told the club's official website.
"Obviously it [is] a big game on Wednesday. Hull beat West Brom on Saturday so they are going to have confidence, but we need to play like we can do at home."
West Ham could perhaps feel hard done by on Saturday - Wayne Rooney scored a stunning goal from distance before pouncing on a miscued Noble clearance to net his second - but they failed to cause any real problems for a makeshift United defence.
Allardyce will demand more of striker Andy Carroll against a Hull side that have the sixth-best defence in the league.
Goals from Liam Rosenior and Shane Long gave Hull their victory over West Brom, taking them to nine Premier League wins for the season.
And manager Bruce believes one more triumph may be enough for the club to secure their position in next season's top flight.
Bruce told Hull's official website: "I've said all along that I thought 10 wins would be enough.
"Whatever it takes, we have to see it through but if we can get to ten wins with seven or eight games to play it means other teams have got to maybe win four and draw a couple which is very difficult."
Hull - who have one eye on their FA Cup semi-final against Sheffield United next month - could be without Long, who suffered a knee injury on Saturday.
George Boyd remains suspended after being found guilty of spitting at Manchester City goalkeeper Joe Hart, while Robbie Brady (groin) and Paul McShane (ankle) are long-term absentees.
Defender Joey O'Brien (dislocated shoulder) and Marco Borriello (calf) are set to miss out for the hosts.