The 25-year-old, who has been shortlisted for April's Premier League Player of the Month award, has scored four goals in his last two matches to take his tally to 21 for the season
The 25-year-old has been shortlisted for April's Premier League Player of the Month award after netting both goals in Swansea's 2-1 win over Newcastle United, as well as scoring twice in the club's 4-1 victory over Aston Villa last Saturday.
The Ivory Coast international's efforts have helped Swansea register consecutive wins for the first time in the Premier League this season, while the club are now mathematically safe from the prospect of relegation.
"We want to break the 40-point barrier and that is the drive for us now," Swansea boss Garry Monk said. "With everything that has gone on this season, if we get past that total, no-one can ever question us.
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In the context of the battles taking place at both ends of the league, this match is off little consequence, with both sides now able to look ahead to another season in the top flight.
While Swansea and Monk chase down the 40 points, Southampton will be celebrating their highest Premier League points total for a 38-game season if they avoid defeat this weekend.
However, the men from the south coast do not tend to travel well to south Wales, failing to pick up a win on their last seven visits, dating back to 1962.
Southampton's home form against Swansea is far better, and they picked up a 2-0 victory when these sides met at St Mary's Stadium back in October.
Doubts remain over the fitness of Michu (ankle), while Swansea full-back Angel Rangel has been ruled out for the remainder of the season with a groin strain, which could see Dwight Tiendalli step in, although Neil Taylor or Kyle Bartley may be preferred to play out of position.
Spanish duo Alejandro Pozuelo and Jose Canas have drifted out of the first-team squad under Monk, casting doubt over their respective Swansea futures, but Jay Fulton could be involved again after coming off the bench to make his debut against Villa last weekend.
Chico Flores is available for selection after serving a two-match suspension, while Southampton will hope to welcome Morgan Schneiderlin back to the fold after he sat out last week's win over Everton.