Having reshuffled his pack at Blackburn on Boxing Day, Tony Pulis is expected to opt for his preferred forward partnership of Ricardo Fuller and Kenwyne Jones, with the former missing out on the trip to Ewood Park as Jonathan Walters took his place.
And despite breaking his goalscoring duck as a substitute in the 2-0 away win, midfielder Marc Wilson is unlikely to start against Fulham, with Rory Delap likely to continue in the middle.
Possible starting XI: Begovic; Wilkinson, Huth, Shawcross, Collins; Pennant, Delap, Whitehead, Etherington; Fuller, Jones.
After seeing his side capitulate against West Ham on Sunday, Mark Hughes may be tempted to mix things up against Stoke, potentially handing Damien Duff a start after the Irishman was only deemed worthy of a spot on the bench against the Hammers.
Possible starting XI: Schwarzer; Pantsil, Hughes, Hangeland, Salcido; Davies, Murphy, Etuhu, Duff; Dempsey; A Johnson.
Broken legs and broken dreams
Tuesday's tie marks these two sides meeting for the first time since an ill tempered League Cup game in September that culminated with Fulham's big summer signing Moussa Dembele sustaining a broken leg as a result of a needless, over-the-top challenge from Andy Wilkinson - one that Hughes would go on to describe as "ridiculous".
Since then, the seasons of both sides have taken a rather different trajectory. At that point of the campaign, the Potters were rooted to the bottom end of the table, but now the Midlands side sit comfortably in the top half while the Londoners struggle down in the relegation zone.
And Tuesday's trip will likely give Fulham fans few reasons to be cheerful, as they have not won an away game this season - another poor display could see another airing of "Hughes out!" from the Cottagers support.