Expect Tony Pulis to make a raft of changes, with Tuncay likely to start up top with Jonathan Walters, and Thomas Sorensen coming in for Asmir Begovic.
Eidur Gudjohnsen could figure at some point to put the Icelandic international in the shop window after a dreadful stay in the Potteries.
Possible starting XI: Sorensen; Wilkinson, Higginbotham, Faye, Collins; Pennant, Whelan, Wilson, Pugh; Tuncay, Walters.
Expect boss Dave Jones to send out a strong eleven as the Welsh side anticipate a Premier League scalp.
Possible starting XI: Heaton; McNaughton, Naylor, Hudson, Quinn; Whittingham, Olofinjana, Burke, Keogh; Chopra, Bellamy.
Rolling back the years
Stoke came within a win of a Wembley semi-final last season, after defeating Arsenal and Manchester City en route to the quarter-finals, and Potters fans will be hoping that their side can go at least a step further this season.
Yet wibbly-wobbly home form of late makes the Midlands side tough to judge, especially when a raft of changes are expected to be made.
And against Cardiff, a team that had Stoke on the ropes many a time in the Football League, the Potters will not be in for an easy ride, but the last meeting between the two sides ended in a 2-1 win for the home team at the Britannia Stadium.
The Championship side, who missed out on promotion last season after being beaten by plucky Blackpool in the play-off final, are flying high in second spot this season.