The team will be checking the fitness of Dean Hammond right up until the morning of the game.
Adam Lallana and David Connolly are also doubts, but new loanee striker Dany N’Guessan with be eligible to play after signing from Leicester City this week.
Possible starting XI: Davis; Richardson, Fonte, Jaidi, Harding; Chamberlain, Chaplow, Schneiderlin, Dickson; Guly, Lambert.
The visitors will be without full-back Rafael after suffering concussion in the team’s game against Blackpool on Tuesday.
Edwin van der Sar has been given the weekend off after his retirement announcement, Patrice Evra will also not be featuring due to family bereavement
Rio Ferdinand is a doubt for the game and will probably be safely rested ahead of United’s game
next Tuesday against Aston Villa. Meanwhile Michael Carrick will face a late fitness test and Sir Alex
Ferguson hopes he will be able to travel to St Mary’s.
Meanwhile, Anders Lindegaard could make his first start for the club ahead of Tomasz Kuszczak.
Possible starting XI: Lindegaard; Neville, Smalling, Vidic, Fabio; Park, Fletcher, Anderson, Giggs;
No pressure, just history
It was in the FA Cup that Southampton won their first major trophy all the way back in 1976 in a
final with just the goal, scored by Bobby Stokes on the 83rd minute against a lacking Manchester
However, the last time these two teams met in the cup was two years ago this month, coming
together in the third round and it was not too pretty for Saturday’s home side with United winning
3-0. Goals from Danny Welbeck, Darron Gibson and a penalty from Nani sealed a comprehensive win over The Saints.
But Nigel Adkin’s side will be looking for an upset on Saturday afternoon and will go into the game
without the pressure that will be lying on United’s backs after cup failure earlier this season.
Top of the tables
League leaders Manchester United are currently the FA Cup’s most decorated club, with 11 wins in a
record 18 finals.
However, the last time they were able to conquer the competition was back in 2004 in a 3-0 win against Millwall and have been runners-up twice since the victory. Arsenal overcame united after a goalless draw after 90 minutes led to penalties with the North London club winning 5-4.
Back in 2007 it was Chelsea’s turn, and in a hard fought out battle that led to extra-time and a single Didier Drogba goal to win it for Jose Mourinho’s team.