Mauricio Pochettino's men welcome the Midlands side to St Mary's Stadium on Wednesday in need of home comforts after losing two successive away games and with their No.1 likely out
Defeats to Arsenal and Chelsea marked the Saints' first consecutive losses since May but they will take confidence from an unbeaten record on their own turf.
They host a Villa side whose strength has generally been on the road this term, having lost just once away from Villa Park all season and racking up nine of their 16 Premier League points as visitors.
Of bigger concern to manager Paul Lambert is the form of Christian Benteke. Last season's talisman has not found the net since September's defeat at home to Newcastle.
|13/8||Southampton are 13/8 with Paddy Power to beat Aston Villa to nil|
Other than that, Mauricio Pochettino has no new injury concerns. Key defender Dejan Lovren returned for the Chelsea game after missing the trip to Arsenal and came through unscathed.
Southampton lie seventh after their latest defeat but victory over Villa could seal a return to the top four. The hosts will be hoping for a repeat of the corresponding fixture last season, when they notched their first win back in the top flight with a 4-1 hammering of Lambert's men.
Villa, currently 11th and six points clear of the drop zone, have a good overall recent record away to the Saints, that hammering their only loss in five previous trips.
They spluttered to a goalless draw at home to Sunderland on Saturday, although the clean sheet was their third in four games and fifth this season - as many as the club put together last term.
The game is likely to come too soon for Joe Bennett (back), with Jores Okore (knee) and Charles N'Zogbia (ankle) long-term absentees.