Luuk de Jong's controversial penalty gave the Dutch side a 1-0 advantage from the first leg, but the hosts will be full of confidence after Sunday's commanding win over Hamburg
Uchida, Metzelder, Papadopoulos, Fuchs
Obasi, Raul, Draxler
Cornelisse, Wisgerhof, Douglas, Rosales
Brama, Fer, Janssen
Chadli, De Jong, O. John
The Gelsenkirchen side played two strikers in Sunday's 3-1 victory over Hamburg, but with Teemu Pukki cup-tied, they should revert to their usual 4-2-3-1 formation, with Chinedu Obasi and Julian Draxler replacing the Finn and Jose Manuel Jurado.
The good news for Huub Stevens is that Kyriakos Papadopoulos is available for this tie after his domestic suspension and should step into the heart of defence, with Joel Matip suspended thanks to his red card in the first leg.
However, Benedikt Howedes is still injured, along with goalkeeping duo Lars Unnerstall and Ralf Fahrmann, whose absences will leave Timo Hildebrand to continue his first-team run.
Twente can welcome back two players who missed Sunday's 3-1 defeat to NEC. Douglas and Willem Janssen both missed the weekend's clash due to suspension, but will return to take the places of Swedish duo Rasmus Bengtsson and Emir Bajrami in defence and midfield respectively.
Elsewhere, Andrej Rendla's long-standing knee problem will keep him out of the Veltins Arena clash, while Wesley Verhoek and Denny Landzaat are back in training, but unlikely to be risked after lengthy absences of their own.
||DID YOU KNOW?|
- Schalke are unbeaten at home in the Europa League this season, having recorded four wins and a draw.
- However, the only clean sheet the Gelsenkirchen outfit have kept on home soil was in the 0-0 draw with AEK Larnaca. Schalke are 7/1 with Bet365 to beat Twente 2-1.
- Schalke have a happy record when entertaining Dutch teams - they've won both of their Veltins Arena encounters with Eredivisie sides 3-0.
- Twente have lost just once on the road in Europe this season - a 1-0 defeat to Fulham in west London.
- The Tukkers' assistant coach Youri Mulder (pictured right) played for Schalke between 1993 and 2002, and was a part of the coaching staff in 2008-09.
- Despite their impressive record away in Europe this season, Twente have won just once in their seven trips to Germany.