The former midfielder left the Parc des Princes to take up his first senior coaching role in May and will now hope to cause an upset against his old employers
Makelele ended his stint as an assistant at PSG in May to make the step up to senior coaching at the Stade Armand Cesari.
The former Chelsea, Real Madrid and PSG midfielder achieved a decent result in his first Ligue 1 game in charge of Bastia, earning a 3-3 home draw Marseille in an enthralling encounter.
But the Corsican outfit are likely to face a much tougher task against defending champions PSG as Blanc and Makelele renew acquaintances for the first time on Saturday.
Blanc was left disappointed as PSG were held to a 2-2 draw in their opening fixture at Reims, and they will be without captain Thiago Silva, who suffered a hamstring injury in Monday's friendly against Napoli.
David Luiz could be the man to take Silva’s place in the PSG back four. Luiz featured in the 2-1 success in Naples, making his first appearance since joining from Chelsea in June.
The former Benfica man completed 78 minutes at the Stadio San Paolo and should be fit to make his full debut alongside another Brazilian Marquinhos.
One player who will not be involved is midfielder Adrien Rabiot, who is still struggling with an ankle injury.