The Frenchman may have to shuffle his pack for his side's first European tie of the campaign with doubts lingering over several players, including Jeremy Menez and Javier Pastore
PSG will take heart from the fact that they reached the quarter-finals last season, where they were knocked out by Barcelona over two legs.
Over the summer, coach Carlo Ancelotti departed for Real Madrid and was replaced by Laurent Blanc and the former France boss has wasted little time in continuing the club's big-spending transfer policy.
Edinson Cavani, Marquinhos and Lucas Digne have all arrived in the French capital and PSG have started the season well, winning three of their five league matches and drawing the other two.
But injury doubts over Alex (thigh), Jeremy Menez (back) and Javier Pastore (foot) mean that Blanc may have to shuffle his pack for the trip to Greece.
Olympiakos won three games in the group stage of last season's Champions League, including two victories over Ligue 1 outfit Montpellier, but still failed to advance to the knockout rounds.
After a busy close season, the Greeks' squad is barely recognisable, with Javier Saviola and Vladimir Weiss headlining a host of summer signings, as just eight of last season's Champions League squad make the cut this time around.