The centre-back misses his side's trip to Carrow Road with an ankle injury, while Chris Hughton's men are looking to end their four-game run without a win
The 25-year-old centre-back, who was named as West Ham's player of the year last season, suffered an ankle injury in training and has been ruled out of the trip to Carrow Road as well as New Zealand's World Cup play-off matches against Mexico.
With both sides struggling for form, West Ham boss Sam Allardyce is under no illusions as to the importance of the clash.
"Norwich is a six-pointer already," he said. "They played well in their last home game against Cardiff (a 0-0 draw) and we have to make sure we frustrate them in that area and be clinical when we get our chances.
"It's not very good injury-wise at the moment other than we've got James Collins back in training.
"Winston Reid (ankle) picked up an unfortunate one this week which adds to the list"
Andy Carroll (heel), Ricardo Vaz Te (shoulder), Alou Diarra (knee) and George McCartney (knee) are also sidelined for West Ham.
Norwich will be looking to bounce back with a positive result against West Ham following their 7-0 hammering at the hands of Manchester City last Saturday.
Chris Hughton's men have gone four games without a victory, while West Ham have not won in three matches since beating Tottenham on October 6.
Norwich welcome back Robert Snodgrass (concussion), but are set to be without Ricky van Wolfswinkel (toe) in addition to Elliott Bennett (knee) and Alexander Tettey (ankle).
Nathan Redmond (hip) faces a late fitness test, and Hughton hopes his charges can put last week's performance behind them.
"Any negatives are in the past. We have faith in the ability that we have. The value of winning a couple of games is huge," said the 54-year-old.