The attacker trained away from the rest of the team on Friday, while his Dutch coach faces his toughest assignment yet as Rossoneri coach with the visit of the Bianconeri
Under the stewardship of the Dutchman, the Rossoneri have played six league matches, winning four and losing just once in a 3-1 reverse at Napoli.
Despite the upturn in fortunes, a massive 31-point gap separates Milan - who have endured a disappointing campaign on the whole and sit ninth - from the Bianconeri.
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Milan have serious doubts over the fitness of forward Balotelli, who picked up a shoulder injury in the recent Champions League defeat to Atletico Madrid.
The Italy international trained separately from the rest of the squad on Friday, while Stephan El Shaarawy and goalkeeper Christian Abbiati are still absent.
Juve are without influential midfielder Arturo Vidal, who will sit out the match through suspension. Defender Giorgio Chiellini is also likely to miss the clash as is wide player Kwadwo Asamoah.
They are, however, able to call on one of the league's deadliest partnerships in the form of Carlos Tevez and Fernando Llorente.
The duo have claimed 24 league goals between them this season and were rested for Juventus' midweek 2-0 victory at Trabzonspor in the Europa League.
Tevez and Llorente can therefore expect to be fresh and ready, along with influential midfielder Paul Pogba, who was withdrawn in the first half on Thursday once Juventus had effectively confirmed their progression to the last-16.
Pablo Osvaldo is another forward option for Conte, with the on-loan Southampton man having bagged his second goal for the club against Trabzonspor.