Antonio Conte's men leapfrogged Roma to go first in Serie A and can cling to the slender lead with a win over a side which have been inconsistent in 2013-14
The reigning champions moved above Roma into top spot thanks to 2-0 victory at Livorno last weekend and will be confident of retaining that position against a club they are unbeaten against in four matches.
Francisco Guidolin's side have made an inconsistent start to the season, having failed to win back-to-back league games and losing four of their last six fixtures.
They have also lost five of their six away Serie A matches this term, with their sole success coming in a 2-1 victory at newly promoted Sassuolo last month.
Goals have not been easy to come by for the 11th-placed Udinese, as only the bottom two have scored fewer times than their total of 12.
To make matters worse for Guidolin, Colombian forward Luis Muriel - who has scored three of their 12 Serie A goals - will miss the trip to the Juventus Stadium with a thigh strain.
The hosts come into the game on the back of a morale-boosting win in the Champions League over Copenhagen, with Arturo Vidal scoring a hat-trick in that game to take him to 10 goals in all competitions this season.
Carlos Tevez will also provide a threat to the Udinese defence, with the Argentina international having contributed 25 per cent of Juventus' league goals this season with seven in 13 appearances since his move from Manchester City in the summer.
Conte will welcome back defenders Stephan Lichsteiner, Andrea Barzagli, and former Udinese man Mauricio Isla, but Sebastian Giovinco and Simone Pepe remain on the sidelines while Kwadwo Asamoah is suspended.