Antonio Conte's men can extend the gap at the top to six points with a victory on Sunday, which would be the perfect tonic for a Champions League hangover
Antonio Conte's side were knocked out of the Champions League after losing 1-0 in snowy Istanbul on Wednesday, much to the disappointment of the coach, and he hopes a return to league action will help ease the pain of their early elimination from Europe's premier club cup competition.
The league leaders are unbeaten in seven domestic matches - keeping clean sheets in each - and with Roma not playing until Monday, they could open up a six-point lead with a win.
Sassuolo, meanwhile, make their first trip to Juventus this weekend hoping to extend a four-game unbeaten run away from home.
Eusebio Di Francesco's side started the season with four consecutive defeats and no wins in seven matches, but have since picked up three victories and held Roma and Napoli to draws.
However, a wounded Juventus could pose a threat to their record and Conte wants his side get back to winning ways quickly.
"We have to dive back into Serie A and this disappointment has to spur us on domestically," Conte said.
"We have another two games before the Christmas break and will then start to think about the Europa League.
"We will try to do our best, just as we wanted to do our best in the Champions League."
Both sides have strikers in form - ironically Juventus own them both – but Sassuolo will be without their leading scorer.
Domenico Berardi – on loan from from the Bianconceri – has scored five goals in his last five appearances but he will miss the trip due to suspension.
Juventus will have their top scorer Carlos Tevez available, but the Argentina international has gone four games without scoring – a record that equals the longest period he has gone without finding the back of the net for the club.
The visitors will also be without Gomes and Emanuele Terranova (both knee), while Conte continues to be without his playmaker Andrea Pirlo (knee) in the centre of midfield, and Claudio Marchisio is suspended.