The goalkeeper kept his side in the contest in the second half as he made a number of brilliant stops to deny Biava, Keita and Felipe Anderson.
Although he was often exposed by Keita down the wing, he demonstrated a brilliant ability to get forward and support the attack, providing the assist for Palacio's second goal.
An energetic performance from the full-back who complemented his defensive stability with a determination to get forward and assist the attack.
A flawless display from Rolando who looked comfortable in possession and solid in the tackle.
The centre-back has enjoyed a solid second half to the season and his aerial prowess and good reading of the game kept Klose quiet.
A superb dislay from the 36-year-old who produced a number of brilliant blocks and interceptions to frustrate the Lazio attack.
Coped well in Cambiasso's absence and offered good protection to the back three.
The Croatian looked composed on the ball and justified claims that he is one of the most promising talents in European football by providing three magnificent assists.
The Brazilian created a number of good chances for his team-mates and killed off the Lazio challenge with a superb strike from the edge of the box.
The 21-year-old terrorised the Lazio defence with his clever movement and scored his ninth league goal of the season with a well-placed shot beyond Berisha.
Palacio was a constant threat to the Lazio defence and showed his clinical nature with two well-taken goals. Will miss next week's clash with Chievo after picking up a booking.
The Albanian goalkeeper commanded his area effectively and could do nothing to prevent any of Inter's goals.
Although he failed to forge a good understanding with Dias and Cana in defence, he was a threat going forward and scored the opener with an instinctive finish.
The Portuguese wing-back produced a number of teasing crosses to test the Inter defence and played a large part in Biava's opener.
The former Sunderland man proved insurmountable in the air though struggled to deal with the pace of Palacio and Icardi.
The Brazilian looked uncomfortable on his return to the side and his poor positioning left Lazio exposed for Inter's first two goals.
A tenacious display from the Nigerian who broke up the Inter attack effectively. However, he did struggle to contain Kovacic in the midfield.
Got into a number of promising goalscoring positions but often proved wasteful in the final third. He did, however, provide the assist for Biava's opener.
He failed to offer sufficient protection to the back four and was consequently subbed off at half time.
The 21-year-old looked dangerous in possession and was always willing to take on the Inter defence. He was unlucky not to get on the scoresheet.
The 19-year-old has made a brilliant impact since being introduced to the first team and he again showed his promise by stretching the Inter defence and testing Handanovic on a number of occasions.
The Germany international looked rusty on his return to the starting line-up and he spurned a glorious chance to get on the scoresheet in stoppage time.
The 40-year-old received a terrific reception from the Nerazzurri faithful on his final home appearance for the club and demonstrated the determination, leadership and stamina that epitomised his illustrious career.
The Algeria international entered the action late on and gave fresh legs to the Nerazzurri midfield.
The veteran striker is likely to leave Inter at the end of the season though he lacked the service in this game to make a meaningful contribution.