The Portuguese is still suspended but Luis Garcia's men could have three of their back four missing through a combination of injuries and bans
Getafe have been thrown into something of a defensive crisis after their 2-0 defeat to Osasuna last time out, with three of their starting back four potentially missing out.
Centre-back Rafa was forced off with a first-half injury, while Roberto Lago and Alvaro Arroyo will serve one-match bans. Sergio Escudero has also been ruled out, while the fitness of Juan Valera and Lisandro Lopez will be assessed before the game.
A 2-1 defeat on their last derby visit to Getafe will give Madrid cause for concern, though, as they aim to keep pace at the top of La Liga on Sunday.
The Bernabeu outfit are currently locked in a three-way tie for the lead in the Spanish top flight, but los Blancos could be left playing catch-up at the Coliseum Alfonso Perez, with Barcelona and Atletico Madrid in action on Saturday.
That said, Getafe would have to go some to beat their illustrious neighbours again, with Carlo Ancelotti's men having lost just two matches this season - against fellow title challengers Barca and Atleti.
Madrid come into this clash off the back of an impressive 5-0 aggregate Copa del Rey semi-final victory over Atleti, and aiming to extend their unbeaten run in the league to 14 matches.
In contrast, Getafe are on the brink of going a 10th match without a win in all competitions, which would be their longest such run since 2008.