New signing Eidur Gudjohnsen could go straight into the match squad after joining from Stoke on loan until the end of the season. He will replace striker Eddie Johnson after he completed a loan move to Preston North End until the end of the campaign.
Goalkeeper Mark Schwarzer is back after helping Australia to the final of the Asian Cup, but will be rested for this match with David Stockdale continuing in goal.
Aaron Hughes is Mark Hughes' only injury worry ahead of the match against the Toon Army, while Dickson Etuhu and Matthew Briggs could be back in the squad after recovering from hamstring and ankle injuries respectively.
Striker Bobby Zamora (broken leg) and Philipe Senderos (calf) are closing in on returns but will come up short for the visit of Newcastle.
Possible starting XI: Stockdale; Pantsil, Hughes, Hangeland, Salcido; Duff, Murphy, Sidwell, Davies; A Johnson, Dempsey.
Midfielder Stephen Ireland will go straight into the squad for the trip to west London. The former Manchester City and Aston Villa player has not featured in the league since the turn of the year and will get an immediate opportunity to recapture the firm he showed for City.
Alan Pardew will still be without Cheik Tiote as he completes his three match suspension following his red card in the 3-1 FA Cup defeat to Stevenage.
Steven Taylor is a doubt with a hamstring injury and will face a late fitness test.
Ryan Taylor (ankle), Hatem Ben Arfa (broken leg) and Dan Gosling (knee) should all be back by the end of the month but Alan Smith is still sidelined.
Possible starting XI: Harper; Simpson, Williamson, Coloccini, Enrique; Barton, Guthrie, Ireland, Nolan, Guttierez; Ameobi.
Fulham buoyed by FA Cup win
Fulham head back into Premier League action still dreaming of the FA Cup after their 4-0 win over Tottenham at the weekend.
The Cottagers put in a storming performance against Harry Redknapp's side which has started talk of targeting the FA Cup final.
But Mark Hughes will know how important Premier League survival is and will want his players to switch their focus back to Newcastle.
With the additions of Eidur Gudjohnsen and Steve Sidwell, and with players returning from injury, things are looking up for Hughes' men.
If they keep replicating their cup performance it will not be long before they are shooting up the table.
Pressure on Newcastle strikers
Both sides found themselves busy on transfer deadline day, bringing in new recruits. Fulham brought in Eidur Gudjohnsen from Stoke while Stephen Ireland checked in at St James' Park.
But one of the big stories of the day was the news that Newcastle sold striker Andy Carroll for a fee in the region of £35 million. The news came as a big shock to everyone at Newcastle and his absence will be a huge loss.
One of the worrying things for Newcastle fans will be the lack of a replacement.
Alan Pardew was rumoured to have been working right up until the last minute of deadline day to bring in a replacement, but his efforts came to no avail.
Now the pressure will be on Shola Ameobi, Leon Best and Peter Lovenkrands to produce the goals in Carroll's absence and keep Newcastle in the Premier League.
No pressure lads.