Moussa Dembele joins the injury list already populated by Philippe Senderos, Bobby Zamora and Fredrik Stoor. The striker is expected to be out for three weeks having suffered damage to his ankle ligaments.
Full backs Carlos Salcido and Chris Baird are in contention to return though, and Andrew Johnson could be in line to start after returning to first team action in recent weeks.
Possible Starting XI: Schwarzer; Baird, Hughes, Hangeland, Salcido; Duff, Greening, Murphy, Davies; Dempsey; Andrew Johnson.
Micah Richards, Gareth Barry and Joleon Lescott are all doubts following England's friendly defeat by France, but Joe Hart, who picked up a back injury during training for the international friendly, is expected to start.
In attack, Emmanuel Adebayor is doubtful with a heel injury and Mario Balotelli completes his suspension following a red card against West Brom, while Carlos Tevez should be fit to play.
Possible Starting XI: Hart; Boateng, Kompany, Kolo Toure, Kolarov; De Jong, Yaya Toure; Adam Johnson, Milner, Silva; Tevez.
A point to prove
When Fulham line up against Manchester City on Sunday, it will have been slightly less than a year since Mark Hughes was sacked unceremoniously by his former employers from Eastlands following a 4-3 victory over Sunderland.
It was an episode that led Hughes to call his old club 'disrespectful', while others could think of much worse labels to hang on them.
No doubt, as diplomatic as Hughes has been with his choice of words regarding his departure from City, at Craven Cottage on Sunday he will be eager to exact some revenge and fire Fulham up the Premier League. Despite having lost only three games from a possible 13, a preponderance of draws means Hughes's side sit 16th in the table, just one point above the bottom three.
Hughes's replacement at City and opposite number on Sunday, Roberto Mancini, has come in for criticism of late as his side has struggled to find the net in what some observers have cited as a negative approach.
While the cracks aren't as evident at board level as they were with Hughes, three games without a win - or a goal - would undoubtedly put the Italian on the back foot come Monday morning.
None of that will matter come the end of the season if City manage to secure a top four spot, however. Mancini looks likely to be afforded the time to make that happen too, but a win at Craven Cottage, while apparently not a 'must', is a game the visitors will be expected to win.