Despite racing into a two-goal lead after a double from the Argentina international, Martin Jol’s resurgent Cottagers side came back to earn a point at Craven Cottage
Despite City starting the more confident, it was the hosts that had the first meaningful effort on target through Clint Dempsey. Gael Clichy tried to be clever with a quick free kick to Micah Richards, though it was under-hit and intercepted by the American, who fired his effort from 25 yards out over the bar.
City broke the deadlock in the 17th minute after some neat build-up play between Samir Nasri and David Silva set up the in-form Aguero. Silva picked up the ball on the edge of the Fulham area before playing it to Nasri, who put in a perfect through ball for Aguero to place it in the bottom corner with consummate ease.
In the 24th minute City almost doubled their lead through Clichy. The summer signing from Arsenal picked up a clearance from a corner and struck it goalwards from 25 yards, which forced Mark Schwarzer into a top class save.
Once more, City went close as they continued to push Fulham further and further back into their own half as Edin Dzeko was denied by Schwarzer. Yaya Toure picked out a fantastic run from Nasri on the edge of the Fulham area and picked out the arriving Dzeko, who struck his shot first time, only for Schwarzer to thwart him once more.
Just 10 seconds into the second half, City stunned Fulham when Aguero doubled his and his side's tally. Clichy pumped a hopeful ball forward from the kick-off, which was nodded down by Dzeko to Aguero, who lashed in a fierce strike from the edge of the area.
In the 55th minute Bobby Zamora scored a fantastic goal to give his side an undeserved route back into the game. Poor marking from Joleon Lescott and Vincent Kompany allowed Zamora too much space to pick his spot before hitting an unstoppable effort into the top corner.
The surprise goal from Zamora seemed to spark the home side into life and they almost drew level just moments later through Moussa Dembele. The striker cut inside and hit a well-struck shot that took a wicked deflection off Lescott that forced Hart into a world-class stop.
Fulham were looking like a completely different side after the Zamora goal and got a deserved equaliser when Danny Murphy scored. Zamora received the ball with his back to goal and laid it back to Murphy, whose first time effort took a deflection to send it past Hart.
Despite Martin Jol still looking for his first Premier League victory as Fulham boss, the fans will be pleased with the spirit shown after going down 2-0 to such an impressive City side, while Roberto Mancini will leave Craven Cottage wondering why they were unable to keep out a previously tame home attack.