This is a test of future prospects for Fabio Capello, as senior squad withdrawals have allowed young talents to stake a claim.
Chelsea duo John Terry and Ashley Cole and Aston Villa’s Gabriel Agbonlahor pulled out of the squad on Sunday evening after picking up injuries in recent Premier League games. Stephen Warnock, Gary Cahill and Carlton Cole have been called up as cover. Frank Lampard is a long-term absentee.
With regular strikers Jermain Defoe and Wayne Rooney (both ankle) injured, and Emile Heskey retired, Capello has revealed he will hand Andy Carroll his debut after he came through an injury worry. The Newcastle forward will start the game along with fellow fresh face Jordan Henderson and the only slightly more experienced Kieran Gibbs.
Other intriguing admissions to the squad include Manchester City’s Micah Richards and Fulham’s Chris Smalling, but unfortunately Arsenal's Jack Wilshere will miss the game after suffering a knock in training. Joe Hart is also out with a back injury.
Possible starting XI: Foster; Richards, Ferdinand, Jagielka, Gibbs; Milner, Gerrard, Barry, Henderson; Walcott; Carroll.
Tottenham’s Younes Kaboul has been drafted in at the last minute to cover for Roma’s Philippe Mexes who picked up a calf injury over the weekend.
The major inclusion for Laurent Blanc is left-back Eric Abidal, who gets his first inclusion since France’s horror World Cup showing.
The French squad has a distinct Premier League essence to it as, along with Kaboul, Chelsea’s Florent Malouda and Arsenal trio Bacary Sagna, Samir Nasri and Gael Clichy are all in contention for a starting spot.
With Nicolas Anelka banned and Karim Benzema misfiring for Madrid, Tottenham and Liverpool-linked Loic Remy may start up front.
Possible starting XI: Lloris; Sagna, Rami, Sakho, Abidal; Diarra, M’Vila; Gourcuff, Nasri, Malouda; Remy.
Settling of old scores in battle of the young ones
England’s last game against France at headquarters was in 1999, when half the England squad were probably still munching on cocoa pops before school. Under the disappointed eye of the Twin Towers, Les Bleues ran out 2-0 winners, and England have not beaten the French since 1997.
With a fresh look to Capello’s squad, perhaps an answer to people calling for an overhaul in the team, the Italian has combined youth with uncapped players. Jay Bothroyd is perhaps the most surprising of these choices, but he is keen to show this is not a flash in the pan.
"Once you get a taste you want to do well and stay in," Bothroyd said. "If I am involved on Wednesday it will be another great day for me."
Another new face, Sunderland’s Jordan Henderson was quick to acknowledge the stab at the big time he has been offered.
He said: "It's a great opportunity for me and a few of the younger lads to show what we can do. I'll do everything to try and take that chance.
Mutiny on le Bounty, just a storm in a tea-cup says Blanc
France have had an overhaul too. Unfortunately, this was enforced after the mutineers from the World Cup were given indefinite relegations from Blanc’s squad. Eric Abidal, who escaped any sanctions for his role, is an intriguing inclusion.
Blanc disagrees, saying: "He has played very often recently and to become a regular at a club like Barcelona is no mean feat.
"He is still a player who can play a major part in the French starting XI."
In what is a fairly young and inexperienced squad – especially after Philippe Mexes' injury – France may be there for the taking. That aside, France have won three of the last five meetings, and always seem to find an extra gear against Blighty.